Disease Models
Genotype to Function - Disease Models Built for Relevance
Our patient-derived and CRISPR-tailored hepatocytes and stellate cells deliver human-relevant insight into disease mechanisms.
Trusted by leading biopharma partners for predictive biology and custom studies.
Patient-derived
Disease
iPSC disease
Stellate cell
Reliability
About Disease Models
Using patient-derived or CRISPR-engineered iPSC lines, we generate disease-matched hepatocytes and hepatic stellate cells with unmatched fidelity.
These models capture disease phenotypes as observed in vivo and are available for a variety of liver-related disorders, including MASLD, liver fibrosis, Alpha-1 Antitrypsin Deficiency, Urea Cycle Disorders, as well as custom gene variants. Paired with high-content imaging and AI-driven analysis, they provide precise insight into disease mechanisms, progression, and therapeutic response.
Precision Gene Editing
CRISPR-edited iPSC lines ranging from single SNPs to complex polygenic backgrounds.
Patient-Derived Models
Access curated iPSC lines from established disease biobanks for authentic patient representation.
Any Genotype
Engineer any genotype into hepatocyte or stellate cell models tailored to your research.
Functional Fidelity
Cells retain full functionality and biological accuracy even after gene editing.
Complex Co-Culture Systems
Ready-to-use monocultures or multi-cell co-cultures for disease modeling.
Our Disease Models
Redefining Liver Disease In Vitro
Validated human cell models recapitulate key disease mechanisms, enabling more predictive discovery and development in various therapeutic areas.
MASLD
Steatosis reimagined in human cells. Our MASLD models reproduce lipid accumulation and metabolic dysfunction in human hepatocytes.
A1ATD
Precision for Alpha-1 Antitrypsin Deficiency. Disease-matched hepatocytes model A1ATD pathology — intracellular A1AT aggregation.
PFIC2
Cholestasis in a dish. Our PFIC2 models recapitulate impaired bile transport and cholestatic phenotypes in human liver cells.
Urea Cycle Disorder
Hyperammonemia modeled pixel-by-pixel. UCDs capture disturbances in nitrogen metabolism and ammonia processing at single-cell resolution.
